PRDM16 controls a brown fat/skeletal muscle switch
نویسندگان
چکیده
منابع مشابه
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.
Brown adipose tissue (BAT) is an energy-dispensing thermogenic tissue that plays an important role in balancing energy metabolism. Lineage-tracing experiments indicate that brown adipocytes are derived from myogenic progenitors during embryonic development. However, adult skeletal muscle stem cells (satellite cells) have long been considered uniformly determined toward the myogenic lineage. Her...
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Brown fat is a specialized tissue that can dissipate energy and counteract obesity through a pattern of gene expression that greatly increases mitochondrial content and uncoupled respiration. PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, while suppressing the expression of genes selective for white fat cells. To determi...
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A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here, we show that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment. These animals developed ...
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The somatic, or body wall, musculature of the Drosophila embryo comprises a pattern of thirty distinct muscles in each hemisegment. A framework for understanding the development of these muscles has recently emerged (Fig. 1). Briefly, muscle progenitors are selected from a localized domain of the mesoderm by a mechanism similar to the well-documented singling out of neuroblasts in the ectoderm....
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ژورنال
عنوان ژورنال: Nature
سال: 2008
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature07182